The effects of Chinese medicines on cAMP/PKA signaling in central nervous system dysfunction.

Authors :: Li L
Fan X
Zhang XT
Yue SQ
Sun ZY
Zhu JQ
Zhang JH
Gao XM
Zhang H
Source :: Brain research bulletin [Brain Res Bull] 2017 Jun; Vol. 132, pp. 109-117. Date of Electronic Publication: 2017 Apr 21.
Publication Year :: 2017
Abstract: Neuropathological injury in the mammalian adult central nervous system (CNS) may cause axon disruption, neuronal death and lasting neurological deficits. Failure of axon regeneration is one of the major challenges for CNS functional recovery. Recently, the cAMP/PKA signaling pathway has been proven to be a critical regulator for neuronal regeneration, neuroplasticity, learning and memory. Also, previous studies have shown the effects of Chinese medicines on the prevention and treatment of CNS dysfunction mediated in part by cAMP/PKA signaling. In this review, the authors discuss current knowledge of the role of cAMP/PKA signaling pathway in neuronal regeneration and provide an overview of the Chinese medicines that may enable CNS functional recovery via this signaling pathway.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Central Nervous System Agents pharmacology
Central Nervous System Diseases physiopathology
Cyclic AMP metabolism
Cyclic AMP-Dependent Protein Kinases metabolism
Drugs, Chinese Herbal pharmacology
Humans
Medicine, Chinese Traditional
Central Nervous System Agents therapeutic use
Central Nervous System Diseases drug therapy
Drugs, Chinese Herbal therapeutic use

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