Back to Search
Start Over
[Research progress on the animal models and treatment strategies of diabetic foot ulcer].
- Source :
-
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2017 Jan 25; Vol. 46 (1), pp. 97-105. - Publication Year :
- 2017
-
Abstract
- The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Disease Models, Animal
Humans
Matrix Metalloproteinase Inhibitors therapeutic use
Matrix Metalloproteinases genetics
Matrix Metalloproteinases metabolism
Mice
Neovascularization, Physiologic physiology
Diabetic Foot etiology
Diabetic Foot genetics
Diabetic Foot therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1008-9292
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28436638
- Full Text :
- https://doi.org/10.3785/j.issn.1008-9292.2017.02.15