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Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
- Source :
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The Journal of nutritional biochemistry [J Nutr Biochem] 2017 Jul; Vol. 45, pp. 39-47. Date of Electronic Publication: 2017 Apr 06. - Publication Year :
- 2017
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Abstract
- Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly divided into five groups: standard diet (control), high-fat diet (DM), high-fat diet plus ethanol (DM-Ethanol), high-fat diet plus 10 mg/L XN (DM-XN) and high-fat diet plus 10 mg/L 8PN (DM-8PN) during 20 weeks. Fasting blood glucose and insulin tolerance tests were performed 1 week before sacrifice. At the end of the study, blood, liver and skeletal muscle were collected. Both XN and 8PN treatments prevented body weight gain; decreased glycemia, triglyceride, cholesterol and alkaline phosphatase levels; and improved insulin sensitivity. Polyphenols promoted hepatic and skeletal muscle AMP-activated protein kinase (AMPK) activation, diminishing the expression of target lipogenic enzymes (sterol regulatory element binding protein-1c and fatty acid synthase) and acetyl-CoA carboxylase activity. Moreover, both XN and 8PN treatments decreased VEGFR-1/VEGFB pathway, involved in fatty acid uptake, and increased AS160 expression, involved in GLUT4 membrane translocation. Presented data demonstrated that both XN and 8PN treatment resulted in AMPK signaling pathway activation, thus suppressing lipogenesis. Their consumption prevented body weight gain and improved plasma lipid profile, with significant improvement of insulin resistance and glucose tolerance. XN- or 8PN-enriched diet could ameliorate diabetic-associated metabolic disturbances by regulating glucose and lipid pathways.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Acetyl-CoA Carboxylase metabolism
Animals
Body Weight drug effects
Diabetes Mellitus, Experimental etiology
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Experimental prevention & control
Diabetes Mellitus, Type 2 etiology
Diabetes Mellitus, Type 2 prevention & control
Diet, High-Fat adverse effects
Glycolysis drug effects
Insulin Resistance
Lipids blood
Male
Mice, Inbred C57BL
Sterol Regulatory Element Binding Protein 2 metabolism
Vascular Endothelial Growth Factor Receptor-1 metabolism
fas Receptor metabolism
Diabetes Mellitus, Type 2 metabolism
Flavanones pharmacology
Flavonoids pharmacology
Propiophenones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4847
- Volume :
- 45
- Database :
- MEDLINE
- Journal :
- The Journal of nutritional biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28431322
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2017.03.006