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[Multidisciplinary treatment of unresectable liver cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1988 Aug; Vol. 15 (8 Pt 2), pp. 2583-9. - Publication Year :
- 1988
-
Abstract
- From January 1984 to December 1987, 63 unresectable liver cancers (22 hepatocellular carcinoma and 41 metastatic liver cancer) were treated with multidisciplinary therapy: partial resection of liver, hepatic arterial infusion, coagulation therapy using microwave tissue coagulator and intratumoral injection of the liver. The median survival period was 5-7 months, and the clinical response rate was 21.6% in these therapies, but there was no statistically significant difference between the treatments. Recently, we usually use degradable starch microspheres (DSM) with anticancer agents in hepatic arterial infusion. Adriamycin + DSM was administered for hepatocellular carcinoma, and Mitomycin C + DSM was used for metastatic liver cancer. The regimens were used for 12 cases, 6 of hepatocellular carcinoma and 6 of metastatic liver cancer, with a response rate of 50%, respectively. We also undertook chemosensitivity tests for liver cancer. The coincidence of clinical response with results of chemosensitivity tests was above 50%. In future, we shall use the most effective anticancer agents for individual tumors with DSM in arterial infusion.
- Subjects :
- Adult
Aged
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular therapy
Combined Modality Therapy
Doxorubicin administration & dosage
Drug Screening Assays, Antitumor
Embolization, Therapeutic
Female
Humans
Hyperthermia, Induced
Infusions, Intra-Arterial
Liver Neoplasms mortality
Liver Neoplasms secondary
Male
Microspheres
Middle Aged
Mitomycin
Mitomycins administration & dosage
Predictive Value of Tests
Remission Induction
Starch administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Liver Neoplasms therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 15
- Issue :
- 8 Pt 2
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 2843127