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Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension.
- Source :
-
Journal of clinical hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)] 2017 Sep; Vol. 19 (9), pp. 910-918. Date of Electronic Publication: 2017 Apr 21. - Publication Year :
- 2017
-
Abstract
- Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P=.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (β=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.<br /> (©2017 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Angiotensin II Type 1 Receptor Blockers therapeutic use
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Blood Pressure Monitoring, Ambulatory methods
Brazil epidemiology
Cardiovascular Diseases physiopathology
Diuretics standards
Diuretics therapeutic use
Echocardiography methods
Enalapril administration & dosage
Enalapril therapeutic use
Female
Humans
Hydrochlorothiazide administration & dosage
Hydrochlorothiazide standards
Hydrochlorothiazide therapeutic use
Hypertension drug therapy
Hypertension epidemiology
Hypertension physiopathology
Losartan administration & dosage
Losartan therapeutic use
Male
Middle Aged
Polysomnography methods
Pulse Wave Analysis methods
Risk Factors
Sleep Apnea, Obstructive epidemiology
Sleep Apnea, Obstructive physiopathology
Blood Pressure physiology
Cardiovascular Diseases epidemiology
Hypertension complications
Sleep Apnea, Obstructive complications
Vascular Stiffness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1751-7176
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of clinical hypertension (Greenwich, Conn.)
- Publication Type :
- Academic Journal
- Accession number :
- 28429850
- Full Text :
- https://doi.org/10.1111/jch.13008