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Impact of hyperglycemia on the efficacy of chemotherapy-A systematic review of preclinical studies.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2017 May; Vol. 113, pp. 235-241. Date of Electronic Publication: 2017 Mar 10. - Publication Year :
- 2017
-
Abstract
- Background: Antineoplastic agents can provoke hyperglycemia in cancer patients with and without diabetes mellitus. We systematically reviewed the impact of hyperglycemia on the efficacy of chemotherapy.<br />Methods: MEDLINE was searched for preclinical intervention studies which compared chemotherapy response in hyperglycemic and euglycemic conditions.<br />Results: Thirteen preclinical studies, including 23 cell lines and 2 animal experiments were identified. In 14 cell lines and 2 animal studies, chemotherapy response was lower in a hyperglycemic (>15mmol/L) compared to a euglycemic environment (5mmol/L). The response was similar in 4 cell lines. In the remaining 5 cell lines, the hyperglycemic environment potentiated chemotherapy efficacy.<br />Conclusion: Hyperglycemia attenuated the antiproliferative effect of chemotherapy in preclinical experiments, but the results are inconsistent. Whether hyperglycemia influences efficacy of chemotherapy in patients needs to be explored.<br /> (Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 113
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 28427512
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2017.03.007