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Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Apr 20; Vol. 18 (4). Date of Electronic Publication: 2017 Apr 20. - Publication Year :
- 2017
-
Abstract
- Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upregulation of miR-221 and downregulation of miR-1 and -133 in TAA specimens. In contrast, upregulation of miR-146a and downregulation of miR-145 and -331-3p were found only for AAA specimens. Upregulation of miR-126 and -486-5p and downregulation of miR-30c-2*, -155, and -204 were observed in specimens of TAAs and AAAs. The data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies. Thus, changes in miR-1, -29a, -133a, and -221 are involved in TAAs and miR-145, -146, and -331-3p impact AAAs. This work validates prior studies on microRNA expression in aneurysmal diseases.
- Subjects :
- Aged
Aortic Aneurysm, Abdominal diagnosis
Aortic Aneurysm, Thoracic diagnosis
Case-Control Studies
Cluster Analysis
Computational Biology methods
Female
Gene Expression Profiling
Genetic Association Studies
Humans
Male
Middle Aged
Risk Factors
Transcriptome
Aortic Aneurysm, Abdominal genetics
Aortic Aneurysm, Thoracic genetics
Genetic Predisposition to Disease
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28425970
- Full Text :
- https://doi.org/10.3390/ijms18040875