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Alpha-1 Antitrypsin Levels and Polymorphisms in Interstitial Lung Diseases.
- Source :
-
Turkish journal of medical sciences [Turk J Med Sci] 2017 Apr 18; Vol. 47 (2), pp. 476-482. Date of Electronic Publication: 2017 Apr 18. - Publication Year :
- 2017
-
Abstract
- Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease.<br />Materials and Methods: A total of 103 interstitial lung disease patients were compared.<br />Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low alpha-1 antitrypsin levels were more frequently observed in nonidiopathic interstitial pneumonia patients compared with idiopathic interstitial pneumonia, but the difference was not statistically significant (8.9% vs. 0%, respectively, P = 0.4). In 100 patients, the normal PiMM genotype was detected, while abnormal ones (PiMZ, n = 2, 1.9%; PiMS, n = 1, 0.97%) were determined in three cases. When the frequency of alpha-1 antitrypsin polymorphism in interstitial lung disease patients was compared with the data of the healthy population, no significant difference was detected for the PiMZ and PiMS variants (P = 0.15 and P = 0.44, respectively).<br />Conclusion: Lower levels of serum alpha-1 antitrypsin were more frequent in nonidiopathic interstitial pneumonia patients than idiopathic interstitial pneumonia without an increase in genetic polymorphism. The difference was not statistically significant.
- Subjects :
- Adult
Aged
Female
Genetic Predisposition to Disease
Humans
Lung Diseases, Interstitial epidemiology
Lung Diseases, Interstitial physiopathology
Male
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
Turkey epidemiology
alpha 1-Antitrypsin Deficiency epidemiology
alpha 1-Antitrypsin Deficiency physiopathology
Lung Diseases, Interstitial diagnosis
Lung Diseases, Interstitial genetics
Polymorphism, Genetic
alpha 1-Antitrypsin blood
alpha 1-Antitrypsin genetics
alpha 1-Antitrypsin Deficiency diagnosis
alpha 1-Antitrypsin Deficiency genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1300-0144
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Turkish journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28425234
- Full Text :
- https://doi.org/10.3906/sag-1508-76