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Segmental Diffusion Properties of the Corticospinal Tract and Motor Outcome in Hemiparetic Children With Perinatal Stroke.
- Source :
-
Journal of child neurology [J Child Neurol] 2017 May; Vol. 32 (6), pp. 550-559. Date of Electronic Publication: 2017 Mar 22. - Publication Year :
- 2017
-
Abstract
- Perinatal stroke injures developing motor systems, resulting in hemiparetic cerebral palsy. Diffusion tensor imaging can explore structural connectivity. We used diffusion tensor imaging to assess corticospinal tract diffusion in hemiparetic children with perinatal stroke. Twenty-eight children (6-18 years) with unilateral stroke underwent diffusion tensor imaging. Four corticospinal tract assessments included full tract, partial tract, minitract and region of interest. Diffusion characteristics (fractional anisotropy, mean, axial, and radial diffusivity) were calculated. Ratios (lesioned/nonlesioned) were compared across segments and to validated long-term motor outcomes (Pediatric Stroke Outcome Measure, Assisting Hand Assessment, Melbourne Assessment). Fractional anisotropy and radial diffusivity ratios decreased as tract size decreased, while mean diffusivity showed consistent symmetry. Poor motor outcomes were associated with lower fractional anisotropy in all segments and radial diffusivity correlated with both Assisting Hand Assessment and Melbourne Assessment. Diffusion imaging of segmented corticospinal tracts is feasible in hemiparetic children with perinatal stroke. Correlations with disability support clinical relevance and utility in model development for personalized rehabilitation.
- Subjects :
- Adolescent
Anisotropy
Child
Child, Preschool
Community Health Planning
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Infant
Male
Stroke diagnostic imaging
Cerebral Palsy etiology
Cerebral Palsy pathology
Diffusion Tensor Imaging
Motor Activity physiology
Pyramidal Tracts diagnostic imaging
Stroke complications
Subjects
Details
- Language :
- English
- ISSN :
- 1708-8283
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28424004
- Full Text :
- https://doi.org/10.1177/0883073817696815