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Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2017 May 25; Vol. 81 (6), pp. 888-890. Date of Electronic Publication: 2017 Apr 18. - Publication Year :
- 2017
-
Abstract
- Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E <superscript>-/-</superscript> mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E <superscript>-/-</superscript> mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.<br />Conclusions: MMP-9 deficiency augmented AngII-induced AAA.
- Subjects :
- Angiotensin II pharmacology
Animals
Aortic Aneurysm, Abdominal chemically induced
Aortic Aneurysm, Abdominal genetics
Aortic Aneurysm, Abdominal pathology
Apolipoproteins E deficiency
Matrix Metalloproteinase 9 genetics
Mice
Mice, Knockout
Relaxin genetics
Angiotensin II adverse effects
Aortic Aneurysm, Abdominal metabolism
Matrix Metalloproteinase 9 metabolism
Relaxin biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1347-4820
- Volume :
- 81
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 28420827
- Full Text :
- https://doi.org/10.1253/circj.CJ-17-0229