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Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation.
- Source :
-
Microbiology and immunology [Microbiol Immunol] 2017 May; Vol. 61 (5), pp. 185-189. - Publication Year :
- 2017
-
Abstract
- Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for measles virus hemagglutinin (MV-H) and immunoglobulin-like variable domain of signaling lymphocyte activation molecule (SLAM-V). It was observed that the docking scores for MV-H and SLAM-V correlated with the activity of SLAM as an MV receptor. These results suggest that the receptor functionality may be predicted from the docking scores of virion surface proteins and cellular receptor molecules.<br /> (© 2017 The Societies and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Animals
Cats
Cattle
Dogs
Humans
Measles veterinary
Measles virology
Mice
Sigmodontinae virology
Hemagglutinins, Viral immunology
Lymphocyte Activation immunology
Measles transmission
Measles virus immunology
Molecular Docking Simulation
Receptors, Virus metabolism
Signaling Lymphocytic Activation Molecule Family metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1348-0421
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28419512
- Full Text :
- https://doi.org/10.1111/1348-0421.12484