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Assessment of the Albumin-Bilirubin (ALBI) Grade as a Prognostic Indicator for Hepatocellular Carcinoma Patients Treated With Radioembolization.
- Source :
-
American journal of clinical oncology [Am J Clin Oncol] 2018 Sep; Vol. 41 (9), pp. 861-866. - Publication Year :
- 2018
-
Abstract
- Objective: As the utility of Child-Pugh (C-P) class is limited by the subjectivity of ascites and encephalopathy, we evaluated a previously established objective method, the albumin-bilirubin (ALBI) grade, as a prognosticator for yttrium-90 radioembolization (RE) treatment for patients with hepatocellular carcinoma (HCC).<br />Materials and Methods: A total of 117 patients who received RE for HCC from 2 academic centers were reviewed and stratified by ALBI grade, C-P class, and Barcelona Clinic Liver Cancer stage. The overall survival (OS) according to these 3 criteria was evaluated by Kaplan-Meier survival analysis. The utilities of C-P class and ALBI grade as prognostic indicators were compared using the log-rank test. Multivariate Cox regression analysis was performed to identify additional predictive factors.<br />Results: Patients with ALBI grade 1 (n=49) had superior OS than those with ALBI grade 2 (n=65) (P=0.01). Meanwhile, no significant difference was observed in OS between C-P class A (n=100) and C-P class B (n=14) (P=0.11). For C-P class A patients, the ALBI grade (1 vs. 2) was able to stratify 2 clear and nonoverlapping subgroups with differing OS curves (P=0.03). Multivariate Cox regression test identified alanine transaminase, Barcelona Clinic Liver Cancer stage, and ALBI grade as the strongest prognostic factors for OS (P<0.10).<br />Conclusions: ALBI grade as a prognosticator has demonstrated clear survival discrimination that is superior to C-P class among HCC patients treated with RE, particularly within the subgroup of C-P class A patients. ALBI grade is useful for clinicians to make decisions as to whether RE should be recommended to patients with HCC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular pathology
Female
Follow-Up Studies
Humans
Liver Neoplasms blood
Liver Neoplasms pathology
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate
Bilirubin blood
Biomarkers, Tumor blood
Carcinoma, Hepatocellular therapy
Chemoembolization, Therapeutic mortality
Liver Neoplasms therapy
Serum Albumin, Human analysis
Technetium Tc 99m Aggregated Albumin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1537-453X
- Volume :
- 41
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- American journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28418940
- Full Text :
- https://doi.org/10.1097/COC.0000000000000384