Back to Search
Start Over
Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats.
- Source :
-
Biological trace element research [Biol Trace Elem Res] 2017 Dec; Vol. 180 (2), pp. 265-274. Date of Electronic Publication: 2017 Apr 17. - Publication Year :
- 2017
-
Abstract
- Cadmium (Cd) is a toxic environmental and occupational pollutant with reported toxic effects on the kidneys, liver, lungs, bones, and the immunity system. Based on its physicochemical similarity to cadmium, zinc (Zn) shows protective effects against cadmium toxicity and cadmium accumulation in the body. Nano-zinc and nano-zinc oxide (ZnO), recently used in foods and pharmaceutical products, can release a great amount of Zn <superscript>2+</superscript> in their environment. This research was carried out to investigate the more potent properties of the metal zinc among sub-acute cadmium intoxicated rats. Seventy-five male Wistar rats were caged in 15 groups. Cadmium chloride (CdCl <subscript>2</subscript> ) was used in drinking water to induce cadmium toxicity. Different sizes (15, 20, and 30 nm) and doses of nano-zinc particles (3, 10, 100 mg/kg body weight [bw]) were administered solely and simultaneously with CdCl <subscript>2</subscript> (2-5 mg/kg bw) for 28 days. The experimental animals were decapitated, and the biochemical biomarkers (enzymatic and non-enzymatic) were determined in their serum after oral exposure to nano-zinc and cadmium. Statistical analysis was carried out with a one-way ANOVA and t test. P < 0.05 was considered as statistically significant. The haematocrit (HCT) significantly increased and blood coagulation time significantly reduced in the nano-zinc-treated rats. AST, ALT, triglyceride, total cholesterol, LDL, and free fatty acids increased significantly in the cadmium- and nano-zinc-treated rats compared with the controls. However, albumin, total protein, and HDLc significantly decreased in the cadmium- and nano-zinc-treated rats compared with the controls (P < 0.05). It seems that in the oral administration of nano-zinc, the smaller sizes with low doses and the larger sizes with high doses are more toxic than metallic zinc. In a few cases, an inverse dose-dependent relationship was seen as well. This research showed that in spite of larger sizes of zinc, smaller sizes of nano-zinc particles are not suitable for protection against cadmium intoxication.
- Subjects :
- Animals
Biomarkers blood
Cadmium chemistry
Cadmium Chloride administration & dosage
Chlorides adverse effects
Chlorides therapeutic use
Dietary Supplements analysis
Environmental Pollutants antagonists & inhibitors
Heavy Metal Poisoning blood
Heavy Metal Poisoning physiopathology
Hematocrit
Male
Metal Nanoparticles adverse effects
Metal Nanoparticles ultrastructure
Microscopy, Electron, Transmission
Oxidants administration & dosage
Oxidants chemistry
Oxidants therapeutic use
Particle Size
Protective Agents administration & dosage
Protective Agents adverse effects
Protective Agents chemistry
Protective Agents therapeutic use
Random Allocation
Rats, Wistar
Renal Insufficiency etiology
Renal Insufficiency prevention & control
Toxicity Tests, Subacute
Whole Blood Coagulation Time
Zinc administration & dosage
Zinc chemistry
Zinc therapeutic use
Zinc Compounds adverse effects
Zinc Compounds therapeutic use
Zinc Oxide administration & dosage
Cadmium toxicity
Dietary Supplements adverse effects
Environmental Pollutants toxicity
Heavy Metal Poisoning etiology
Metal Nanoparticles administration & dosage
Oxidants adverse effects
Zinc adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0720
- Volume :
- 180
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological trace element research
- Publication Type :
- Academic Journal
- Accession number :
- 28417309
- Full Text :
- https://doi.org/10.1007/s12011-017-1008-0