Back to Search
Start Over
The anti-inflammatory effect of tramadol in the temporomandibular joint of rats.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2017 Jul 15; Vol. 807, pp. 82-90. Date of Electronic Publication: 2017 Apr 12. - Publication Year :
- 2017
-
Abstract
- Tramadol is a centrally acting analgesic drug able to prevent nociceptor sensitization when administered into the temporomandibular joint (TMJ) of rats. The mechanism underlying the peripheral anti-inflammatory effect of tramadol remains unknown. This study demonstrated that intra-TMJ injection of tramadol (500µg/TMJ) was able to inhibit the nociceptive response induced by 1.5% formalin or 1.5% capsaicin, suggesting that tramadol has an antinociceptive effect, acting directly on the primary nociceptive neurons activating the nitric oxide/cyclic guanosine monophosphate signaling pathway. Tramadol also inhibited the nociceptive response induced by carrageenan (100µg/TMJ) or 5-hydroxytryptamine (225µg/TMJ) along with inhibition of inflammatory cytokines levels, leukocytes migration and plasma extravasation. In conclusion, the results demonstrate that peripheral administration of tramadol has a potential antinociceptive and anti-inflammatory effect. The antinociceptive effect is mediated by activation of the intracellular nitric oxide/cyclic guanosine monophosphate pathway, at least in part, independently from the opioid system.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
CD55 Antigens metabolism
Capsaicin pharmacology
Cell Adhesion Molecules metabolism
Cyclic GMP metabolism
Dose-Response Relationship, Drug
Interleukin-1beta metabolism
Male
Nitric Oxide metabolism
Nociception drug effects
Rats
Rats, Wistar
Temporomandibular Joint metabolism
Tumor Necrosis Factor-alpha metabolism
Analgesics pharmacology
Anti-Inflammatory Agents pharmacology
Temporomandibular Joint drug effects
Tramadol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 807
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28412371
- Full Text :
- https://doi.org/10.1016/j.ejphar.2017.04.012