Back to Search
Start Over
Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection.
- Source :
-
The Journal of infection [J Infect] 2017 Jul; Vol. 75 (1), pp. 26-34. Date of Electronic Publication: 2017 Apr 13. - Publication Year :
- 2017
-
Abstract
- Objectives: We sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (URI) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients.<br />Methods: Nasopharyngeal (NP) samples were collected from 74 acute otitis media (AOM) infection-prone and 754 non-prone children during 2094 healthy visits, 673 viral URI visits and 631 AOM visits. Three otopathogens Streptococcus pneumoniae (Spn), Nontypeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis (Mcat) were identified by culture.<br />Results: NP colonization rates of multiple otopathogens during health were significantly lower than during viral URI, and during URI they were lower than at onset of upper respiratory bacterial infection in both AOM infection-prone and non-prone children. AOM infection-prone children had higher polymicrobial colonization rates than non-prone children during health, viral URI and AOM. Polymicrobial colonization rates of AOM infection-prone children during health were equivalent to that of non-prone children during viral URI, and during viral URI were equivalent to that of non-prone during AOM infection. Spn colonization was positively associated with NTHi and Mcat colonization during health, but negatively during AOM infection.<br />Conclusion: The infection-prone patients more frequently have multiple potential bacterial pathogens in the NP than the non-prone patients. Polymicrobial interaction in the NP differs during health and at onset of infection.<br /> (Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Acute Disease epidemiology
Bacteria classification
Bacteria isolation & purification
Bacterial Infections epidemiology
Bacterial Infections immunology
Bacterial Infections microbiology
Child, Preschool
Coinfection immunology
Disease Susceptibility epidemiology
Disease Susceptibility microbiology
Female
Haemophilus influenzae isolation & purification
Haemophilus influenzae physiology
Healthy Volunteers
Humans
Infant
Longitudinal Studies
Male
Moraxella catarrhalis isolation & purification
Moraxella catarrhalis physiology
Otitis Media microbiology
Prospective Studies
Respiratory Tract Infections epidemiology
Streptococcus pneumoniae isolation & purification
Streptococcus pneumoniae physiology
Coinfection epidemiology
Coinfection microbiology
Nasopharynx microbiology
Respiratory Tract Infections microbiology
Respiratory Tract Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2742
- Volume :
- 75
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infection
- Publication Type :
- Academic Journal
- Accession number :
- 28412081
- Full Text :
- https://doi.org/10.1016/j.jinf.2017.04.003