Back to Search
Start Over
Current and future role of genetic screening in gynecologic malignancies.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2017 Nov; Vol. 217 (5), pp. 512-521. Date of Electronic Publication: 2017 Apr 12. - Publication Year :
- 2017
-
Abstract
- The world of hereditary cancers has seen exponential growth in recent years. While hereditary breast and ovarian cancer and Lynch syndrome account for the majority of mutations encountered by gynecologists, newly identified deleterious genetic mutations continue to be unearthed with their associated risks of malignancies. However, these advances in genetic cancer predispositions then force practitioners and their patients to confront the uncertainties of these less commonly identified mutations and the fact that there is limited evidence to guide them in expected cancer risk and appropriate risk-reduction strategies. Given the speed of information, it is imperative to involve cancer genetics experts when counseling these patients. In addition, coordination of screening and care in conjunction with specialty high-risk clinics, if available, allows for patients to have centralized management for multiple cancer risks under the guidance of physicians with experience counseling these patients. The objective of this review is to present the current literature regarding genetic mutations associated with gynecologic malignancies as well to propose screening and risk-reduction options for these high-risk patients.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- AMP-Activated Protein Kinase Kinases
DNA Mismatch Repair genetics
DNA Polymerase III genetics
DNA-Binding Proteins genetics
Epithelial Cell Adhesion Molecule genetics
Fanconi Anemia Complementation Group Proteins genetics
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Genital Neoplasms, Female genetics
Hamartoma Syndrome, Multiple diagnosis
Hamartoma Syndrome, Multiple genetics
Hereditary Breast and Ovarian Cancer Syndrome diagnosis
Hereditary Breast and Ovarian Cancer Syndrome genetics
Humans
Li-Fraumeni Syndrome diagnosis
Li-Fraumeni Syndrome genetics
Lynch Syndrome II diagnosis
Lynch Syndrome II genetics
Mismatch Repair Endonuclease PMS2 genetics
MutL Protein Homolog 1 genetics
MutS Homolog 2 Protein genetics
Neoplastic Syndromes, Hereditary genetics
PTEN Phosphohydrolase genetics
Peutz-Jeghers Syndrome diagnosis
Peutz-Jeghers Syndrome genetics
Protein Serine-Threonine Kinases genetics
RNA Helicases genetics
Tumor Suppressor Protein p53 genetics
Genital Neoplasms, Female diagnosis
Neoplastic Syndromes, Hereditary diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 217
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 28411145
- Full Text :
- https://doi.org/10.1016/j.ajog.2017.04.011