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APR-246/PRIMA-1 MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

Authors :
Peng X
Zhang MQ
Conserva F
Hosny G
Selivanova G
Bykov VJ
Arnér ES
Wiman KG
Source :
Cell death & disease [Cell Death Dis] 2017 Apr 13; Vol. 8 (4), pp. e2751. Date of Electronic Publication: 2017 Apr 13.
Publication Year :
2017

Details

Language :
English
ISSN :
2041-4889
Volume :
8
Issue :
4
Database :
MEDLINE
Journal :
Cell death & disease
Publication Type :
Academic Journal
Accession number :
28406483
Full Text :
https://doi.org/10.1038/cddis.2016.137