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Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes.
- Source :
-
Oncotarget [Oncotarget] 2017 Apr 25; Vol. 8 (17), pp. 28725-28735. - Publication Year :
- 2017
-
Abstract
- TROP2 is a transmembrane glycoprotein that is overexpressed in various cancers. Emerging evidence suggests that TROP2-targeting therapies are efficacious and safe in patients with multiple prior treatments. TROP2 is a promising target for lung cancer treatment; however, little is known regarding the association of TROP2 expression with clinicopathological/molecular features, including prognosis, in lung cancer. We examined consecutive cases of adenocarcinoma, squamous cell carcinoma (SqCC), and high-grade neuroendocrine tumor (HGNET) for the membranous expression of TROP2 using immunohistochemistry. High TROP2 expression was observed in 64% (172/270) of adenocarcinomas, 75% (150/201) of SqCCs, and 18% (21/115) of HGNETs. Intriguingly, the association of TROP2 expression with mortality was dependent on the lung cancer subtype. High TROP2 expression was associated with higher lung cancer-specific mortality in adenocarcinomas [univariable hazard ratio (HR) = 1.60, 95% confidence interval (CI) = 1.07-2.44, P = 0.022)], but not in SqCCs (univariable HR = 0.79, 95% CI = 0.35-1.94, P = 0.79). In HGNETs, high TROP2 expression was associated with lower lung cancer-specific mortality in both univariable and multivariable analyses (multivariable HR = 0.13, 95% CI = 0.020-0.44, P = 0.0003). Our results suggest a differential role for TROP2 in different lung cancer subtypes.
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma mortality
Antigens, Neoplasm genetics
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell mortality
Cell Adhesion Molecules genetics
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Lung Neoplasms diagnosis
Lung Neoplasms mortality
Male
Middle Aged
Molecular Targeted Therapy
Neuroendocrine Tumors diagnosis
Neuroendocrine Tumors mortality
Prognosis
Survival Analysis
Up-Regulation
Adenocarcinoma genetics
Antigens, Neoplasm metabolism
Biomarkers, Tumor metabolism
Carcinoma, Squamous Cell genetics
Cell Adhesion Molecules metabolism
Lung Neoplasms genetics
Neuroendocrine Tumors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 8
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 28404926
- Full Text :
- https://doi.org/10.18632/oncotarget.15647