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Preserved endothelial progenitor cell angiogenic activity in African American essential hypertensive patients.
- Source :
-
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2018 Mar 01; Vol. 33 (3), pp. 392-401. - Publication Year :
- 2018
-
Abstract
- Background: African American (AA) subjects with essential hypertension (EH) have greater inflammation and cardiovascular complications than Caucasian EH. An impaired endogenous cellular repair system may exacerbate vascular injury in hypertension, yet whether these differ between AA EH and Caucasian EH remains unknown. Vascular repair by circulating endothelial progenitor cells (EPCs) is controlled by regulators of EPC mobilization, homing, adhesion and new vessel formation, but can be hindered by various cytokines. We hypothesized that EPC levels and function would be impaired in AA EH compared with Caucasian EH, in association with increased levels of inflammatory mediators and EPC regulators.<br />Methods: CD34+/KDR+ EPCs were isolated from inferior vena cava and renal vein blood samples of AA EH and Caucasian EH patients (nā=ā18 each) and from peripheral veins of 17 healthy volunteers (HVs) and enumerated using fluorescence-activated cell sorting. Angiogenic function of late-outgrowth endothelial cells expanded from these samples for 3 weeks was tested in vitro. Levels of inflammatory mediators, angiogenic factors and EPC regulators were measured by Luminex.<br />Results: EPC levels were decreased in both AA and Caucasian EH compared with HVs, whereas their late-outgrowth endothelial cell angiogenic function was comparable. Levels of several inflammatory mediators were elevated in AA EH compared with Caucasian EH and HVs. Contrarily, vascular endothelial growth factor and its receptor-2 were lower. EPC levels inversely correlated with blood pressure in all hypertensive patients and estimated glomerular filtration rate with inflammatory mediators only in AA EH.<br />Conclusions: Despite lower EPC numbers, decreased vascular endothelial growth factor signaling and inflammation, EPC function is preserved in AA EH compared with Caucasian EH and HVs, suggesting compensatory mechanisms for vascular repair.<br /> (© The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
- Subjects :
- Aged
Blood Pressure physiology
Case-Control Studies
Cells, Cultured
Endothelial Progenitor Cells metabolism
Essential Hypertension metabolism
Female
Glomerular Filtration Rate
Humans
Inflammation metabolism
Male
Middle Aged
Prospective Studies
Black or African American statistics & numerical data
Endothelial Progenitor Cells cytology
Essential Hypertension physiopathology
Inflammation pathology
Neovascularization, Physiologic
Vascular Endothelial Growth Factor A metabolism
White People statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2385
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Publication Type :
- Academic Journal
- Accession number :
- 28402508
- Full Text :
- https://doi.org/10.1093/ndt/gfx032