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B-Cell and Classical Hodgkin Lymphomas Associated With Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 2.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2017 Feb 01; Vol. 147 (2), pp. 153-170. - Publication Year :
- 2017
-
Abstract
- Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology submitted small and large B-cell lymphomas (BCLs), including classical Hodgkin lymphoma (CHL), in the context of immunodeficiency.<br />Methods: Clinicopathologic and molecular features were studied to explore unifying concepts in malignant B-cell proliferations across immunodeficiency settings.<br />Results: Cases submitted to the workshop spanned small BCLs presenting as nodal or extranodal marginal zone lymphoma and lymphoplasmacytic lymphoma, Epstein-Barr virus (EBV) positive in 75% of cases. Submitted large BCLs formed a spectrum from diffuse large B-cell lymphoma (DLBCL) to CHL across immunodeficiency settings. Additional studies demonstrated overexpression of PD-L1 and molecular 9p24 alterations in the large BCL spectrum and across different immunodeficiency settings.<br />Conclusions: Small BCLs occur in all immunodeficiency settings, and EBV positivity is essential for their recognition as immunodeficiency related. Large BCLs include a spectrum from DLBCL to CHL across all immunodeficiency settings; immunohistochemical and molecular features are suggestive of shared pathogenetic mechanisms involving PD-L1 immune checkpoints.<br /> (© American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com)
- Subjects :
- Education
Female
Humans
Male
Epstein-Barr Virus Infections complications
Hodgkin Disease immunology
Hodgkin Disease pathology
Hodgkin Disease virology
Immunologic Deficiency Syndromes immunology
Immunologic Deficiency Syndromes pathology
Immunologic Deficiency Syndromes virology
Lymphoma, B-Cell immunology
Lymphoma, B-Cell pathology
Lymphoma, B-Cell virology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 147
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 28395108
- Full Text :
- https://doi.org/10.1093/ajcp/aqw216