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The duck beta-globin gene cluster contains a single enhancer element.

Authors :
Kretsovali A
Marcaud L
Huesca M
Scherrer K
Source :
FEBS letters [FEBS Lett] 1988 Jul 18; Vol. 234 (2), pp. 300-4.
Publication Year :
1988

Abstract

An erythroid-specific enhancer was previously identified in the 3'-flanking region of the beta adult gene in chicken and duck, by transfection into AEV transformed chicken erythroblasts. Here we show that the duck enhancer is equally active in erythroid human K562 cells, presenting an embryonic/fetal program of globin gene expression. Furthermore, no other enhancer was found within the 20 kb of DNA including four beta-like globin genes as well as a 1.5 kb upstream and a 3 kb downstream sequence.

Details

Language :
English
ISSN :
0014-5793
Volume :
234
Issue :
2
Database :
MEDLINE
Journal :
FEBS letters
Publication Type :
Academic Journal
Accession number :
2839370
Full Text :
https://doi.org/10.1016/0014-5793(88)80103-0