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A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE.
- Source :
-
International journal of cardiology [Int J Cardiol] 2017 Aug 15; Vol. 241, pp. 97-102. Date of Electronic Publication: 2017 Apr 04. - Publication Year :
- 2017
-
Abstract
- Background: The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE).<br />Methods: From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or prosthesis valve endocarditis (PVE) were operated on in 26 Italian Cardiac Surgery Centers. The relationship between early mortality and covariates was evaluated with logistic mixed effect models. Fixed effects are parameters associated with the entire population or with certain repeatable levels of experimental factors, while random effects are associated with individual experimental units (centers).<br />Results: Early mortality was 11.0% (298/2715); At mixed effect logistic regression the following variables were found associated with early mortality: age class, female gender, LVEF, preoperative shock, COPD, creatinine value above 2mg/dl, presence of abscess, number of treated valve/prosthesis (with respect to one treated valve/prosthesis) and the isolation of Staphylococcus aureus, Fungus spp., Pseudomonas Aeruginosa and other micro-organisms, while Streptococcus spp., Enterococcus spp. and other Staphylococci did not affect early mortality, as well as no micro-organisms isolation. LVEF was found linearly associated with outcomes while non-linear association between mortality and age was tested and the best model was found with a categorization into four classes (AUC=0.851).<br />Conclusions: The following study provides a logistic risk model to predict early mortality in patients with heart valve or prosthesis infective endocarditis undergoing surgical treatment, called "The EndoSCORE".<br /> (Copyright © 2017. Published by Elsevier B.V.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cardiac Surgical Procedures trends
Female
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
Retrospective Studies
Treatment Outcome
Cardiac Surgical Procedures mortality
Endocarditis diagnosis
Endocarditis mortality
Heart Valve Prosthesis microbiology
Prosthesis-Related Infections diagnosis
Prosthesis-Related Infections mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 241
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 28390740
- Full Text :
- https://doi.org/10.1016/j.ijcard.2017.03.148