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Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2017 Jun; Vol. 54, pp. 199-213. Date of Electronic Publication: 2017 Mar 18. - Publication Year :
- 2017
-
Abstract
- Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Diffusion Tensor Imaging
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Sensorimotor Cortex physiology
Cognition physiology
Cognitive Aging physiology
Cognitive Aging psychology
Executive Function physiology
Rest psychology
White Matter diagnostic imaging
White Matter physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 54
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 28389085
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2017.01.027