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Differentiation of Inflammatory from Fibrotic Ileal Strictures among Patients with Crohn's Disease through Analysis of Time-Intensity Curves Obtained after Microbubble Contrast Agent Injection.
- Source :
-
Ultrasound in medicine & biology [Ultrasound Med Biol] 2017 Jun; Vol. 43 (6), pp. 1171-1178. Date of Electronic Publication: 2017 Apr 04. - Publication Year :
- 2017
-
Abstract
- The aim of the study described here was to assess whether the analysis of time-intensity curves obtained after microbubble contrast agent injection could differentiate inflammatory from fibrotic ileal strictures among patients with Crohn's disease. Sixty-five consecutive patients (40 male and 25 female; mean age ± SD, 42.2 ± 12.22 y) with stricture of the terminal ileal loop from Crohn's disease were scanned after microbubble injection. Time-intensity curves were obtained from quantitative analysis, and peak enhancement, rise time, time to peak, area under the time-intensity curve (AUC), AUC during wash-in (AUCWI) and AUC during wash-out (AUCWO) were compared between patients with inflammatory strictures and patients with fibrotic strictures. Inflammatory (n = 40) and fibrotic (n = 25) strictures differed (p < 0.05) in peak enhancement, wash-in rate, wash-in perfusion index, AUC, AUCWI and AUCWO. The quantitative analysis of small bowel wall contrast enhancement after microbubble contrast agent injection may differentiate inflammatory from fibrotic ileal strictures in patients with Crohn's disease.<br /> (Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Computer Simulation
Constriction, Pathologic diagnostic imaging
Constriction, Pathologic metabolism
Constriction, Pathologic pathology
Contrast Media pharmacokinetics
Crohn Disease complications
Diagnosis, Differential
Female
Fibrosis metabolism
Fibrosis pathology
Humans
Ileitis etiology
Male
Metabolic Clearance Rate
Models, Biological
Reproducibility of Results
Sensitivity and Specificity
Crohn Disease diagnostic imaging
Crohn Disease metabolism
Fibrosis diagnostic imaging
Ileitis diagnostic imaging
Ileitis metabolism
Image Interpretation, Computer-Assisted methods
Phospholipids pharmacokinetics
Sulfur Hexafluoride pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-291X
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ultrasound in medicine & biology
- Publication Type :
- Academic Journal
- Accession number :
- 28385471
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2017.01.024