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Immune Cell Subsets Evaluation as a Predictive Tool for Hepatitis B Infection Outcome and Treatment Responsiveness.
- Source :
-
Folia medica [Folia Med (Plovdiv)] 2017 Mar 01; Vol. 59 (1), pp. 53-62. - Publication Year :
- 2017
-
Abstract
- Background: The patient's immune response is one of the major factors influencing HBV eradication or chronification, and it is thought to be responsible for the treatment success.<br />Aim: Our study aimed to investigate whether cellular defense mechanisms are associated with the course of HBV infection (spontaneous recovery [SR] or chronification [CHB]) and with the therapeutic approach.<br />Patients and Methods: A total of 139 patients (118 with CHB, 21 SR) and 29 healthy individuals (HI) were immunophenotyped by flowcytometry. Fifty-six patients were treatment-naïve, 20 were treated with interferons and 42 with nucleoside/ nucleotide analogues.<br />Results: Deficiency of T lymphocytes, helper-inducer (CD3+CD4+), suppressorcytotoxic (CD8+CD3+) and cytotoxic (CD8+CD11b-, CD8+CD28+) subsets, activated T cells (CD3+HLA-DR+, CD8+CD38+) and increased CD57+CD8- cells, elevated percentages of B lymphocytes and NKT cells were observed in CHB patients compared with HI. In SR patients, elevated CD8+CD11b+, NKT and activated T cells were found in comparison with controls. The higher values of T cells and their subsets in SR patients than in CHB patients reflect a recovery of cellular immunity in resolved HBV infection individuals. In both groups of treated patients, reduced T lymphocytes, CD3+CD4+ and CD8+CD38+ subsets were found in comparison with HI. Higher proportions of cytotoxic subsets were observed in treated patients compared with treatment-naïve CHB patients, more pronounced in the group with interferon therapy.<br />Conclusion: Our data demonstrate that cellular immune profiles may be of prognostic value in predicting the clinical course of HBV infection, and the determination of the therapeutic response.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Antiviral Agents therapeutic use
Case-Control Studies
Disease Progression
Female
Flow Cytometry
Hepatitis B immunology
Hepatitis B, Chronic drug therapy
Humans
Immunophenotyping
Interferon-alpha therapeutic use
Male
Middle Aged
Natural Killer T-Cells immunology
Polyethylene Glycols therapeutic use
Recombinant Proteins therapeutic use
Remission, Spontaneous
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Helper-Inducer immunology
Treatment Outcome
Young Adult
B-Lymphocyte Subsets immunology
Hepatitis B, Chronic immunology
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0204-8043
- Volume :
- 59
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Folia medica
- Publication Type :
- Academic Journal
- Accession number :
- 28384114
- Full Text :
- https://doi.org/10.1515/folmed-2017-0008