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Neuropsychiatric symptoms in Alzheimer's disease: associations with caregiver burden and treatment outcomes.
- Source :
-
QJM : monthly journal of the Association of Physicians [QJM] 2017 Sep 01; Vol. 110 (9), pp. 565-570. - Publication Year :
- 2017
-
Abstract
- Background: Caregivers play a major role in providing care for patients with Alzheimer's disease (AD) and are themselves at higher risk of health comorbidities.<br />Aim: To address the impact of neuropsychiatric symptoms of patients in different stages of AD on their caregivers' burden.<br />Design: This prospective study enrolled 260 AD patients with clinical dementia rating (CDR) of 0.5, 1 and 2 at a tertiary medical center.<br />Methods: All patients were tested using the mini-mental state examination (MMSE), the cognitive abilities screening instrument (CASI), the neuropsychiatric inventory (NPI) and the CDR scale. Data regarding therapeutic outcomes of anti-Alzheimer's drugs were also collected. Caregivers were tested using NPI.<br />Results: The mean follow-up interval was 25.0 ± 12.2 months, and two patients died during follow-up. NPI-burden was positively correlated with NPI-sum ( r = 0.822, P < 0.001) but negatively correlated with years of education ( r = -0.140, P = 0.024), CASI score ( r = -0.259, P < 0.001) and MMSE score ( r = -0.262, P <0.001). Multiple linear regression analysis showed that only NPI-sum was independently associated with mean NPI-burden. Both higher mean CASI and MMSE scores had better therapeutic outcome of anti-Alzheimer's drugs ( P = 0.001 and P = 0.005, respectively).<br />Conclusions: The severity of neuropsychiatric symptoms in patients with AD was positively associated with caregiver's stress, and patients with better cognitive functions, under treatment with anti-Alzheimer's drugs, had better therapeutic outcomes. To reduce the impact of neuropsychiatric symptoms, it is crucial to detect dementia in its early phases and provide early intervention with anti-Alzheimer's drugs, which might help decrease the caregiver burden, thereby improving their quality of life.<br /> (© The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com)
- Subjects :
- Adaptation, Psychological
Aged
Aged, 80 and over
China
Cognition
Female
Humans
Male
Mental Competency psychology
Middle Aged
Neuropsychological Tests
Prospective Studies
Psychiatric Status Rating Scales
Treatment Outcome
Alzheimer Disease diagnosis
Alzheimer Disease psychology
Alzheimer Disease therapy
Behavioral Symptoms diagnosis
Behavioral Symptoms etiology
Behavioral Symptoms therapy
Caregivers psychology
Cost of Illness
Nootropic Agents therapeutic use
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2393
- Volume :
- 110
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- QJM : monthly journal of the Association of Physicians
- Publication Type :
- Academic Journal
- Accession number :
- 28383687
- Full Text :
- https://doi.org/10.1093/qjmed/hcx077