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Identification and characterization of a human G9P[23] rotavirus strain from a child with diarrhoea in Thailand: evidence for porcine-to-human interspecies transmission.
- Source :
-
The Journal of general virology [J Gen Virol] 2017 Apr; Vol. 98 (4), pp. 532-538. Date of Electronic Publication: 2017 Apr 06. - Publication Year :
- 2017
-
Abstract
- An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8-N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
- Subjects :
- Animals
Cluster Analysis
Feces virology
Genome, Viral
Humans
Infant
Phylogeny
Rotavirus isolation & purification
Rotavirus Infections transmission
Sequence Analysis, DNA
Sequence Homology
Swine
Thailand
Zoonoses transmission
Zoonoses virology
Diarrhea virology
Genotype
Rotavirus classification
Rotavirus genetics
Rotavirus Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 98
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 28382902
- Full Text :
- https://doi.org/10.1099/jgv.0.000722