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Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobutanes.
- Source :
-
Organic letters [Org Lett] 2017 Apr 21; Vol. 19 (8), pp. 2114-2117. Date of Electronic Publication: 2017 Apr 04. - Publication Year :
- 2017
-
Abstract
- Combining an efficient preparation of cyclobutenylmetal species, high-yielding cross-coupling reactions, and highly diastereoselective [4 + 2]-cycloaddition led to opening a new route toward the synthesis of fused alkylidenecyclobutanes containing up to five consecutive stereocenters. New complex architectures, analogues to protoilludane skeletons, were obtained in a very efficient manner and with a minimum number of steps starting from commercial sources and were tested for their cytotoxicity against leukemia cell lines HL60.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28374585
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b00724