T Cells in Celiac Disease.

Authors :: Jabri B
Sollid LM
Source :: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Apr 15; Vol. 198 (8), pp. 3005-3014.
Publication Year :: 2017
Abstract: Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.<br /> (Copyright © 2017 by The American Association of Immunologists, Inc.)