Back to Search
Start Over
Expansion and retention of pulmonary CD4 + T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia.
- Source :
-
Vaccine [Vaccine] 2017 May 02; Vol. 35 (19), pp. 2575-2581. Date of Electronic Publication: 2017 Mar 31. - Publication Year :
- 2017
-
Abstract
- Francisella tularensis subsp. tularensis strain SchuS4 (Ftt) is a highly virulent intracellular bacterium. Inhalation of 10 or fewer organisms results in an acute and potentially lethal disease called pneumonic tularemia. Ftt infections occur naturally in the U.S. and Ftt was developed as a bioweapon. Thus, there is a need for vaccines that protect against this deadly pathogen. Although a live vaccine strain of Francisella tularensis (LVS) exists, LVS fails to generate long-lived protective immunity against modest challenge doses of Ftt. We recently identified an important role for high avidity CD4 <superscript>+</superscript> T cells in short-term protection and hypothesized that expanding this pool of cells would improve overall vaccine efficacy with regard to longevity and challenge dose. In support of our hypothesis, application of a prime/boost vaccination strategy increased the pool of high avidity CD4 <superscript>+</superscript> T cells which correlated with improved survival following challenge with either increased doses of virulent Ftt or at late time points after vaccination. In summary, we demonstrate that both epitope selection and vaccination strategies that expand antigen-specific T cells correlate with superior immunity to Ftt as measured by survival.<br /> (Copyright © 2017. Published by Elsevier Ltd.)
- Subjects :
- Animals
Disease Models, Animal
Epitopes, T-Lymphocyte immunology
Female
Immunization Schedule
Mice, Inbred C57BL
Survival Analysis
Tularemia prevention & control
United States
Bacterial Vaccines administration & dosage
Bacterial Vaccines immunology
CD4-Positive T-Lymphocytes immunology
Francisella tularensis immunology
Lung immunology
Tularemia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 35
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 28372827
- Full Text :
- https://doi.org/10.1016/j.vaccine.2017.03.064