MYD88 L265P mutation in cutaneous involvement by Waldenström macroglobulinemia.

Authors :: Alegría-Landa V
Prieto-Torres L
Santonja C
Córdoba R
Manso R
Requena L
Rodríguez-Pinilla SM
Source :: Journal of cutaneous pathology [J Cutan Pathol] 2017 Jul; Vol. 44 (7), pp. 625-631. Date of Electronic Publication: 2017 May 05.
Publication Year :: 2017
Abstract: Cutaneous manifestations of Waldenström macroglobulinemia (WM) may occur because of several mechanisms, the least common being direct skin infiltration by neoplastic cells. We report a case of patient that after 4-year history of indolent WM developed skin infiltration by lymphoplasmacytoid cells in the form of a small, mildly indurated plaque on the anterior chest. MYD88 L265P mutation was detected both in the previous bone marrow biopsy and in the cutaneous lesion. We review the impact of this new genetic tool in the diagnosis and treatment of lymphoplasmacytic proliferations.<br /> (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)