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Pupil segmentation adaptive optics for invivo mouse retinal fluorescence imaging.
- Source :
-
Optics letters [Opt Lett] 2017 Apr 01; Vol. 42 (7), pp. 1365-1368. - Publication Year :
- 2017
-
Abstract
- Adaptive Optics (AO) for scanning laser ophthalmoscopy enables high-resolution retinal imaging that can be used for preclinical research of diseases causing vision loss. Pupil Segmentation (PS) is an approach to wavefront-sensorless AO that acquires images within subregions across the imaging pupil to measure the wavefront slopes at the corresponding locations of the beam. We present PS-AO as an approach to correct ocular aberrations in ∼7 s, implemented to minimize respiratory motion from an anesthetized mouse. We demonstrated an improvement in resolution and an image intensity increase of ∼25% across all results using PS-AO for in vivo fluorescence retinal imaging in mice using a MEMS-based segmented deformable mirror.
Details
- Language :
- English
- ISSN :
- 1539-4794
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Optics letters
- Publication Type :
- Academic Journal
- Accession number :
- 28362770
- Full Text :
- https://doi.org/10.1364/OL.42.001365