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Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of β-Carbolines.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2017 Apr 21; Vol. 82 (8), pp. 4435-4443. Date of Electronic Publication: 2017 Mar 31. - Publication Year :
- 2017
-
Abstract
- Synthesis of substituted β-carbolines was accomplished by utilizing the catalytic enolate arylation reaction of ketones in conjunction with several 3-bromoindole derivatives. Quenching of the arylation reaction in situ with an electrophile allowed ready incorporation of functionality at the carboline C-4 position in an efficient one-pot protocol.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 82
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28362489
- Full Text :
- https://doi.org/10.1021/acs.joc.7b00299