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Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese Type 2 Diabetic ZSF1 Rats.
- Source :
-
Nutrients [Nutrients] 2017 Mar 31; Vol. 9 (4). Date of Electronic Publication: 2017 Mar 31. - Publication Year :
- 2017
-
Abstract
- Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w / w ) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio. More importantly, WGP intake improved the renal function as urination and proteinuria decreased, or it prevented kidney tissue damage in these diabetic rats. The renal protection of WGP diet was associated with up-regulation of antioxidants ( Dhcr24 , Gstk1 , Prdx2 , Sod2 , Gpx1 and Gpx4 ) and downregulation of Txnip (for ROS production) in the kidneys. Furthermore, addition of grape extract reduced H₂O₂-induced cell death of cultured podocytes. In conclusion, daily intake of WGP reduces the progression of kidney disease in obese diabetic rats, suggesting a protective function of antioxidant-rich grape diet against CKD in the setting of MetS.
- Subjects :
- Animals
Antioxidants isolation & purification
Antioxidants metabolism
Biomarkers blood
Biomarkers urine
Cell Line
Crosses, Genetic
Diabetic Nephropathies complications
Diabetic Nephropathies metabolism
Diabetic Nephropathies physiopathology
Disease Progression
Fruit chemistry
Gene Expression Regulation
Kidney metabolism
Kidney pathology
Kidney physiopathology
Male
Metabolic Syndrome complications
Mice
Organ Size
Oxidative Stress
Plant Preparations isolation & purification
Plant Preparations metabolism
Podocytes metabolism
Podocytes pathology
Random Allocation
Rats, Inbred SHR
Rats, Zucker
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic metabolism
Renal Insufficiency, Chronic physiopathology
Antioxidants therapeutic use
Diabetes Mellitus, Type 2 complications
Diabetic Nephropathies diet therapy
Dietary Supplements
Plant Preparations therapeutic use
Renal Insufficiency, Chronic diet therapy
Vitis chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 28362355
- Full Text :
- https://doi.org/10.3390/nu9040345