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Upregulation of the vascular alpha-1 receptor in malignant DOCA-salt hypertension.
- Source :
-
Clinical and experimental hypertension. Part A, Theory and practice [Clin Exp Hypertens A] 1988; Vol. 10 (2), pp. 229-47. - Publication Year :
- 1988
-
Abstract
- In this investigation we describe regulation of the vascular alpha-1 receptor and functional properties of resistance vessels in malignant hypertensive DOCA-salt rats (DOCA-salt). Uninephrectomized control and DOCA-salt rats were maintained for 6 weeks; microscopic renal morphology provided an index of vascular injury. Radioligand binding studies indicated a striking increase in the density of mesenteric alpha-1 binding sites in DOCA-salt (542 +/- 44 fm/mg) vs. salt control (206 +/- 4 fm/mg) and water control (223 +31 fm/mg) P less than .01. The affinity of the receptor for the radioligand [125I] (+/-) BE 2254 was reduced in DOCA-salt rats. Electrical nerve stimulation and agonist dose response curves were performed on isolated perfused mesenteric arteries. A singular correlation between increased receptor density and vascular responses in DOCA-salt rats could not be demonstrated. The norepinephrine (NE) content of mesenteric arteries was reduced in DOCA-salt (1001 +/- 32 ng/g) vs. water control (1522 +/- 44 ng/g) and saline control (1538 +/- 30 ng/g) P less than .01. Our results indicate, upregulation of the mesenteric alpha-1 receptor occurs in DOCA-salt rats, however, additional factors participate in the vascular response to adrenergic stimulation in this model.
- Subjects :
- Animals
Desoxycorticosterone
Hypertension chemically induced
Hypertension physiopathology
Male
Mesenteric Arteries drug effects
Mesenteric Arteries metabolism
Mesenteric Arteries physiology
Nephrectomy
Phenethylamines metabolism
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha drug effects
Hypertension metabolism
Receptors, Adrenergic, alpha metabolism
Tetralones
Subjects
Details
- Language :
- English
- ISSN :
- 0730-0077
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental hypertension. Part A, Theory and practice
- Publication Type :
- Academic Journal
- Accession number :
- 2836114
- Full Text :
- https://doi.org/10.3109/10641968809103525