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Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K⁺ ATP Channel Pathways in Chronic Constriction Injury in Mice Model.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2017 Mar 30; Vol. 22 (4). Date of Electronic Publication: 2017 Mar 30. - Publication Year :
- 2017
-
Abstract
- The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of l-arginine-NO-cGMP-K⁺ was assessed by the von Frey and the Randall-Selitto tests. Both allodynia and hyperalgesia assessments were carried out on the 14th day post CCI, 30 min after treatments were given for each respective pathway. Anti-allodynic and antihyperalgesic effects of zerumbone (10 mg/kg, i.p) were significantly reversed by the pre-treatment of l-arginine (10 mg/kg), 1H [1,2,4]Oxadiazole[4,3 a ]quinoxalin-1-one (ODQ), a soluble guanosyl cyclase blocker (2 mg/kg i.p.) and glibenclamide (ATP-sensitive potassium channel blocker) (10 mg/kg i.p.) ( p < 0.05). Taken together, these results indicate that systemic administration of zerumbone produces significant anti-allodynic and antihyperalgesic activities in neuropathic pain in mice possibly due to involvement of the l-arginine-NO-cGMP-PKG-K⁺ ATP channel pathways in CCI model.
- Subjects :
- Analgesics pharmacology
Animals
Arginine metabolism
Constriction
Cyclic GMP metabolism
Disease Models, Animal
Hyperalgesia metabolism
KATP Channels metabolism
Male
Mice
Neuralgia etiology
Neuralgia metabolism
Nitric Oxide metabolism
Pain Measurement
Sesquiterpenes pharmacology
Analgesics administration & dosage
Hyperalgesia drug therapy
Neuralgia drug therapy
Sesquiterpenes administration & dosage
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 28358309
- Full Text :
- https://doi.org/10.3390/molecules22040555