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A Novel PPh 3 Mediated One-Pot Method for Synthesis of 3-Aryl or Alkyl 1,2-Benzisoxazoles.
- Source :
-
Organic letters [Org Lett] 2017 Apr 07; Vol. 19 (7), pp. 1792-1795. Date of Electronic Publication: 2017 Mar 30. - Publication Year :
- 2017
-
Abstract
- A novel, efficient, and facile protocol has been developed for transforming 2-hydroxybenzonitriles and bromides into a range of 3-aryl or alkyl substituted 1,2-benzisoxazoles in good to excellent yields mediated by PPh <subscript>3</subscript> . The electronic and steric effects of bromides on the reaction are discussed. This is the first example to construct a C-C bond and heterocycle in a Barbier-Grignard-type reaction featuring easier recovery of PPh <subscript>3</subscript> than a metallic catalyst in one step.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28357871
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b00563