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Blockade of β2-adrenoceptor, rather than β1-adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts.
- Source :
-
Cardiology journal [Cardiol J] 2017; Vol. 24 (4), pp. 403-408. Date of Electronic Publication: 2017 Mar 29. - Publication Year :
- 2017
-
Abstract
- Background: Cardiac anaphylaxis is one of the features of anaphylactic hypotension. Patients treated with propranolol, a nonselective β-adrenoceptor (AR) antagonist, develop severe anaphylaxis, but the mechanism remains unknown. Under examination were the effects of β1- and β2-AR antagonist on anaphylaxis-induced coronary vasoconstriction and cardiac dysfunction in isolated blood-perfused rat hearts.<br />Methods: Isolated hearts from ovalbumin-sensitized Wistar rats were subjected to coronary perfusion with blood at a constant pressure and measurements were made of coronary blood flow and left ventricu-lar (LV) pressure. Following pretreatment with selective β2-AR antagonist ICI118,551 or selective β1-AR antagonist atenolol, cardiac anaphylaxis was induced by intracoronary injections of ovalbumin antigen. LV contractility was evaluated by the maximum increasing rate of systolic LV pressure (dP/dtmax).<br />Results: In response to antigen administrations, ICI118,551 pretreated hearts showed a greater de-crease in coronary blood flow and consequently a greater increase in coronary vascular resistance than the atenolol pretreated hearts. Pretreatment with ICI118,551 caused a greater decrease in dP/dtmax than those with atenolol.<br />Conclusions: Cardiac anaphylaxis-induced contractile dysfunction and coronary spasm are severe in b2-, rather than β1-AR antagonist, pretreated isolated blood-perfused rat hearts.
- Subjects :
- Anaphylaxis metabolism
Anaphylaxis physiopathology
Animals
Coronary Vasospasm metabolism
Coronary Vasospasm physiopathology
Coronary Vessels physiopathology
Disease Models, Animal
Isolated Heart Preparation
Male
Myocardial Contraction drug effects
Ovalbumin
Rats, Wistar
Receptors, Adrenergic, beta-1 drug effects
Receptors, Adrenergic, beta-1 metabolism
Receptors, Adrenergic, beta-2 drug effects
Receptors, Adrenergic, beta-2 metabolism
Time Factors
Ventricular Dysfunction, Left metabolism
Ventricular Dysfunction, Left physiopathology
Ventricular Pressure drug effects
Adrenergic beta-1 Receptor Antagonists toxicity
Adrenergic beta-2 Receptor Antagonists toxicity
Anaphylaxis chemically induced
Atenolol toxicity
Coronary Vasospasm chemically induced
Coronary Vessels drug effects
Propanolamines toxicity
Vasoconstriction drug effects
Ventricular Dysfunction, Left chemically induced
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1898-018X
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cardiology journal
- Publication Type :
- Academic Journal
- Accession number :
- 28353311
- Full Text :
- https://doi.org/10.5603/CJ.a2017.0034