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Anti-inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive-induced insulin resistance are glucocorticoid-independent.
- Source :
-
Pharmacological reports : PR [Pharmacol Rep] 2017 Jun; Vol. 69 (3), pp. 512-519. Date of Electronic Publication: 2016 Dec 19. - Publication Year :
- 2017
-
Abstract
- Background: Reports showed that estrogen-progestin oral contraceptive (COC) or tobacco smoking causes increased risk of cardiovascular diseases (CVD) in premenopausal women. Studies also suggest that nicotine, a major tobacco alkaloid, may worsen or improve atherothrombotic CVD. Altered hemorheology, prothrombotic and pro-inflammatory biomarkers, have been implicated in the development of atherothrombotic CVD events. However, the effect of non-smoking nicotine exposure on these biomarkers during COC treatment is not yet established. We therefore sought to determine the effects of nicotine exposure during COC treatment on these biomarkers, and also tested the hypothesis that the nicotine effects would be glucocorticoid-dependent.<br />Methods: Female Sprague-Dawley rats aged 10 weeks were given (po) vehicle, low-dose nicotine (0.1mg/kg) or high-dose nicotine (1.0mg/kg) with or without COC steroids (5.0μg/kg ethinylestradiol and 25.0μg/kg levonorgestrel) daily for 6 weeks.<br />Results: COC treatment or nicotine exposure led to increased insulin resistance (IR), hemorheological (blood viscosity, hematocrit and plasma viscosity), prothrombotic (plasminogen activator inhibitor-1), pro-inflammatory (uric acid, C-reactive protein, neutrophil/lymphocyte and platelet/lymphocyte ratios) biomarkers and corticosterone. However, these effects except that on corticosterone were abrogated by nicotine exposure during COC treatment.<br />Conclusions: Our study indicates that nicotine- or COC-induced IR may be mediated via inflammatory/thrombotic pathway. The results imply that nicotine exposure could impact negatively on atherothrombotic biomarkers in COC non-users, whereas the impact in COC users could be positive. The results also suggest that the anti-inflammatory, antithrombotic and blood viscosity-lowering effects of nicotine exposure during COC use is circulating glucocorticoid-independent.<br /> (Copyright © 2016. Published by Elsevier Urban & Partner Sp. z o.o.)
- Subjects :
- Animals
Anti-Inflammatory Agents administration & dosage
Blood Viscosity drug effects
Contraceptives, Oral administration & dosage
Corticosterone metabolism
Dose-Response Relationship, Drug
Drug Combinations
Ethinyl Estradiol administration & dosage
Ethinyl Estradiol toxicity
Female
Fibrinolytic Agents administration & dosage
Fibrinolytic Agents pharmacology
Glucocorticoids metabolism
Levonorgestrel administration & dosage
Levonorgestrel toxicity
Nicotine administration & dosage
Nicotinic Agonists administration & dosage
Nicotinic Agonists pharmacology
Rats
Rats, Sprague-Dawley
Anti-Inflammatory Agents pharmacology
Contraceptives, Oral toxicity
Insulin Resistance
Nicotine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2299-5684
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pharmacological reports : PR
- Publication Type :
- Academic Journal
- Accession number :
- 28349880
- Full Text :
- https://doi.org/10.1016/j.pharep.2016.12.010