Components of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on A β 1-42 -Induced PC12 Cells Injury.

Authors :: Huang HC
Wang CF
Gu JF
Chen J
Hou XF
Zhong RL
Xia Z
Zhao D
Yang N
Wang J
Tan XB
Jia XB
Di LQ
Dong ZB
Feng L
Source :: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2017; Vol. 2017, pp. 7593027. Date of Electronic Publication: 2017 Mar 02.
Publication Year :: 2017
Abstract: Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on A β <subscript>1-42</subscript> -induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by microdialysis (MD) for in vivo sampling. Meanwhile, the protection of components identified was also verified. At last, we found that Goutengsan has a potential protective effect on A β <subscript>1-42</subscript> -induced PC12 cells via reducing cells damage and increasing cells vitality as well as six components (pachymic acid, liquiritin, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine) which may be effective components. This study helps to understand the treatment of Goutengsan for AD and would facilitate the clinical and further studies for this formula.<br />Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.

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