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Characteristics of early-onset hematotoxicity of sunitinib in Japanese patients with renal cell carcinoma.
- Source :
-
BMC cancer [BMC Cancer] 2017 Mar 23; Vol. 17 (1), pp. 214. Date of Electronic Publication: 2017 Mar 23. - Publication Year :
- 2017
-
Abstract
- Background: A high incidence of severe hematological adverse events during sunitinib treatment complicates decision making on dose and treatment cycle. We identified the characteristics of early-onset hematotoxicity of sunitinib in Japanese patients with renal cell carcinoma (RCC).<br />Methods: Seventy-nine patients were treated with sunitinib as 6-week cycles of "4-week on 2-week off" schedule. To evaluate early-onset hematotoxicity, we compared patients with dose reduction during the first cycle (dose-reduced group, n = 57) and those who maintained the initial dose (dose-maintained group, n = 22). ABCG2 and FLT3 genotypes were analyzed for association between hematotoxicity and reported gene polymorphisms.<br />Results: Mean relative dose intensity (RDI) was similar in the two groups during the first 2 weeks of dosing in the first cycle, but was significantly lower in the dose-reduced group during the last 2 weeks. Lymphocytopenia and thrombocytopenia were observed in the dose-reduced group within the first 2 weeks. Genetic analysis indicated a significantly higher frequency of FLT3 738 T/C polymorphism in the dose-reduced group, but no significant difference in the ABCG2 421 C/A polymorphism.<br />Conclusions: This study showed a high incidence of sunitinib-induced hematotoxicity in Japanese patients with RCC, many of whom need dose adjustment during the first cycle. Further studies should verify whether dose adjustment based on early-onset thrombocytopenia prolongs sunitinib treatment.
- Subjects :
- Aged
Female
Humans
Japan
Male
Middle Aged
Retrospective Studies
Sunitinib
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Antineoplastic Agents therapeutic use
Carcinoma, Renal Cell drug therapy
Indoles administration & dosage
Indoles adverse effects
Indoles therapeutic use
Kidney Neoplasms drug therapy
Pyrroles administration & dosage
Pyrroles adverse effects
Pyrroles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 28335742
- Full Text :
- https://doi.org/10.1186/s12885-017-3205-9