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A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats.
- Source :
-
Nutrients [Nutrients] 2017 Mar 13; Vol. 9 (3). Date of Electronic Publication: 2017 Mar 13. - Publication Year :
- 2017
-
Abstract
- Hepatic lipid accumulation and oxidative stress are crucial pathophysiological mechanisms for non-alcoholic fatty liver disease (NAFLD). Thus, we examined the effect of a combination of flaxseed oil (FO) and astaxanthin (ASX) on hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet. ASX was dissolved in flaxseed oil (1 g/kg; FO + ASX). Animals were fed diets containing 20% fat, where the source was lard, or 75% lard and 25% FO + ASX, or 50% lard and 50% FO + ASX, or FO + ASX, for 10 weeks. Substitution of lard with FO + ASX reduced steatosis and reduced hepatic triacylglycerol and cholesterol. The combination of FO and ASX significantly decreased hepatic sterol regulatory element-binding transcription factor 1 and 3-hydroxy-3-methylglutaryl-CoA reductase but increased peroxisome proliferator activated receptor expression. FO + ASX significantly suppressed fatty acid synthase and acetyl CoA carboxylase but induced carnitine palmitoyl transferase-1 and acyl CoA oxidase expression. FO + ASX also significantly elevated hepatic SOD, CAT and GPx activity and GSH, and markedly reduced hepatic lipid peroxidation. Thus, FO and ASX may reduce NAFLD by reversing hepatic steatosis and reducing lipid accumulation and oxidative stress.
- Subjects :
- Acetyl-CoA Carboxylase genetics
Acetyl-CoA Carboxylase metabolism
Animals
Cholesterol metabolism
Diet, High-Fat
Dietary Fats
Fatty Acid Synthases genetics
Fatty Acid Synthases metabolism
Lipid Peroxidation drug effects
Liver metabolism
Male
Non-alcoholic Fatty Liver Disease physiopathology
Oxidoreductases genetics
Oxidoreductases metabolism
PPAR gamma genetics
PPAR gamma metabolism
Rats
Rats, Sprague-Dawley
Sterol Regulatory Element Binding Protein 1 genetics
Sterol Regulatory Element Binding Protein 1 metabolism
Triglycerides blood
Xanthophylls administration & dosage
Linseed Oil administration & dosage
Liver drug effects
Non-alcoholic Fatty Liver Disease diet therapy
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 28335388
- Full Text :
- https://doi.org/10.3390/nu9030271