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Pathogenesis of meningococcal purpura fulminans.
- Source :
-
Pathogens and disease [Pathog Dis] 2017 Apr 01; Vol. 75 (3). - Publication Year :
- 2017
-
Abstract
- Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives.<br /> (© FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Blood Coagulation
Genetic Predisposition to Disease
Host-Pathogen Interactions genetics
Host-Pathogen Interactions immunology
Humans
Meningococcal Infections immunology
Neisseria meningitidis immunology
Purpura Fulminans blood
Meningococcal Infections complications
Meningococcal Infections microbiology
Purpura Fulminans etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 75
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 28334263
- Full Text :
- https://doi.org/10.1093/femspd/ftx027