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Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy.
- Source :
-
European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2017 Oct 01; Vol. 18 (10), pp. 1120-1127. - Publication Year :
- 2017
-
Abstract
- Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT.<br />Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Aged
Cardiac Imaging Techniques methods
Cohort Studies
Confidence Intervals
Europe
Female
Heart Failure mortality
Heart Failure physiopathology
Heart Failure therapy
Humans
Internationality
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Risk Assessment
Statistics, Nonparametric
Survival Rate
Treatment Outcome
Ventricular Dysfunction, Left mortality
Ventricular Remodeling physiology
Cardiac Resynchronization Therapy methods
Echocardiography methods
Magnetic Resonance Imaging, Cine methods
Multimodal Imaging methods
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Dysfunction, Left therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2047-2412
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European heart journal. Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 28329299
- Full Text :
- https://doi.org/10.1093/ehjci/jex021