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White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.
- Source :
-
Journal of neurovirology [J Neurovirol] 2017 Aug; Vol. 23 (4), pp. 539-547. Date of Electronic Publication: 2017 Mar 21. - Publication Year :
- 2017
-
Abstract
- The objective of the current study was to quantify the degree of white matter (WM) abnormalities in chronic and virally suppressed HIV-infected (HIV+) persons while carefully taking into account demographic and disease factors. Diffusion tensor imaging (DTI) was conducted in 40 HIV- and 82 HIV+ men with comparable demographics and life style factors. The HIV+ sample was clinically stable with successful viral control. Diffusion was measured across 32 non-colinear directions with a b-value of 1000 s/mm <superscript>2</superscript> ; fractional anisotropy (FA) and mean diffusivity (MD) maps were quantified with Itrack IDL. Using the ENIGMA DTI protocol, FA and MD values were extracted for each participant and in 11 skeleton regions of interest (SROI) from standard labels in the JHU ICBM-81 atlas covering major striato-frontal and parietal tracks. We found no major differences in FA and MD values across the 11 SROI between study groups. Within the HIV+ sample, we found that a higher CNS penetrating antiretroviral treatment, higher current CD4+ T cell count, and immune recovery from the nadir CD4+ T cell count were associated with increased FA and decreased MD (p < 0.05-0.006), while HIV duration, symptomatic, and asymptomatic cognitive impairment were associated with decreased FA and increased MD (p < 0.01-0.004). Stability of HIV treatment and antiretroviral CNS penetration efficiency in addition to current and historical immune recovery were related to higher FA and lower MD (p = 0.04-p < 0.01). In conclusion, WM DTI measures are near normal except for patients with neurocognitive impairment and longer HIV disease duration.
- Subjects :
- Aged
Anisotropy
Antiretroviral Therapy, Highly Active
Brain immunology
Brain virology
Brain Mapping
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
Cognitive Dysfunction drug therapy
Cognitive Dysfunction immunology
Cognitive Dysfunction virology
Diffusion Tensor Imaging
HIV Infections drug therapy
HIV Infections immunology
HIV Infections virology
HIV-1 drug effects
HIV-1 physiology
Homosexuality, Male
Humans
Male
Middle Aged
Prospective Studies
Time Factors
Viral Load drug effects
White Matter immunology
White Matter virology
Anti-HIV Agents therapeutic use
Brain diagnostic imaging
Cognitive Dysfunction diagnostic imaging
HIV Infections diagnostic imaging
White Matter diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1538-2443
- Volume :
- 23
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neurovirology
- Publication Type :
- Academic Journal
- Accession number :
- 28324319
- Full Text :
- https://doi.org/10.1007/s13365-017-0524-1