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Risk of Diabetes Treated in Early Adulthood After Growth Hormone Treatment of Short Stature in Childhood.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2017 Apr 01; Vol. 102 (4), pp. 1291-1298. - Publication Year :
- 2017
-
Abstract
- Context: Growth hormone (GH) is known to be diabetogenic, but the risk of diabetes in individuals treated with GH in childhood has been little evaluated, and conflicting results have been obtained.<br />Objective: To investigate the prevalence of diabetes and gestational diabetes in a population-based cohort of patients treated with GH for short stature in childhood in France.<br />Design, Setting, and Participants: Participants were a population-based cohort of 5100 children with idiopathic isolated GH deficiency, idiopathic short stature, or short stature in children born short for gestational age who started GH treatment between 1985 and 1996. Data on the delivery of diabetes drugs in 2009 and 2010 were obtained from the French national health insurance database. Cases in patients and controls were identified from diabetes drugs deliveries.<br />Main Outcome Measure: The prevalence of diabetes was calculated and compared with that in the general population, determined on the basis of data from the same source, with the same definition.<br />Results: At a mean age of 30 years, no difference in the prevalence of treated diabetes (oral drugs or insulin) was found between subjects treated with GH and the general population in France, regardless of sex. Similarly, the risk of insulin-treated gestational diabetes was similar in patients and in the reference population.<br />Conclusions: No difference in the risk of diabetes was found between GH-treated patients and the reference population. These results are reassuring, but further studies with a longer follow-up are required to evaluate the risk of diabetes with age in these patients.<br /> (Copyright © 2017 by the Endocrine Society)
- Subjects :
- Adult
Age of Onset
Body Height
Child
Child, Preschool
Female
France epidemiology
Hormone Replacement Therapy adverse effects
Hormone Replacement Therapy statistics & numerical data
Human Growth Hormone adverse effects
Humans
Infant, Newborn
Infant, Small for Gestational Age growth & development
Male
Pregnancy
Prevalence
Risk Factors
Diabetes Mellitus epidemiology
Diabetes, Gestational epidemiology
Growth Disorders drug therapy
Growth Disorders epidemiology
Human Growth Hormone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 102
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 28324032
- Full Text :
- https://doi.org/10.1210/jc.2016-3145