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Development of Curcumin loaded chitosan polymer based nanoemulsion gel: In vitro, ex vivo evaluation and in vivo wound healing studies.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2017 Aug; Vol. 101, pp. 569-579. Date of Electronic Publication: 2017 Mar 16. - Publication Year :
- 2017
-
Abstract
- In the present study, various nanoemulsions were prepared using Labrafac PG+Triacetin as oil, Tween 80 as a surfactant and polyethylene glycol (PEG 400) as a co-surfactant. The developed nanoemulsions (NE1-NE5) were evaluated for physicochemical characterizations and ex-vivo for skin permeation and deposition studies. The highest skin deposition was observed for NE2 with 46.07% deposition amongst all developed nanoemulsions (NE1-NE5). Optimized nanoemulsion (NE2) had vesicle size of 84.032±0.023nm, viscosity 78.23±22.2 cps, refractive index 1.404. Nanoemulsion gel were developed by incorporation of optimized nanoemulsion (NE2) into 1-3% chitosan and characterized by physical evaluation and rheological studies. Chitosan gel (2%) was found to be suitable for gelation of nanoemulsion based on its consistency, feel and ease of spreadability. The flux of nanoemulsion gel was found 68.88μg/cm <superscript>2</superscript> /h as compared to NE2 (76.05μg/cm <superscript>2</superscript> /h) is significantly lower suggesting limited skin permeation of curcumin form gel. However, the retained amount of curcumin on skin by gel formulation (980.75±88μg) is significantly higher than NE2 (771.25±67μg). Enhanced skin permeation of NE2 (46.07%) was observed when compared to nanoemulsion gel (31.25%) and plain gel (11.47%). The outcome of this study evidently points out the potential of curcumin entrapped nanoemulsion gel in wound healing.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Biocompatible Materials metabolism
Curcumin metabolism
Emulsions
Gels
Permeability
Polyethylene Glycols chemistry
Polysorbates chemistry
Rats
Skin metabolism
Solubility
Surface-Active Agents chemistry
Thermodynamics
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Chitosan chemistry
Curcumin chemistry
Curcumin pharmacology
Nanostructures chemistry
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 101
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 28322948
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2017.03.066