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Insulin resistance and cognitive performance in type 2 diabetes - The Maastricht study.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2017 May; Vol. 31 (5), pp. 824-830. Date of Electronic Publication: 2017 Feb 12. - Publication Year :
- 2017
-
Abstract
- Aims: Type 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment. Experimental studies indicate that insulin signaling in the brain is related to cognitive performance. Here we evaluated whether insulin-related variables contribute to the variance in cognitive performance among individuals with type 2 diabetes.<br />Methods: A total of 806 individuals with type 2 diabetes (mean age 62±8years, HbA1c 6.9±1.1%) completed a neuropsychological test battery. Insulin-related variables evaluated were: fasting plasma insulin, C-peptide, and the Homeostasis Model Assessment (HOMA2-IR; in individuals without insulin treatment; n=641). The unadjusted coefficient of determination (R <superscript>2</superscript> ), obtained from multiple linear regression analyses, was used to estimate the proportion of variance in cognition explained by insulin-related variables.<br />Results: Sex, age, and educational level together explained 18.0% (R <superscript>2</superscript> ) of the variance in memory function, 26.5% in information processing speed, and 22.8% in executive function and attention. Fasting insulin, C-peptide, or HOMA2-IR did not increase the explained variance (maximum ΔR <superscript>2</superscript> 0.3%, P≥0.14). Similar results were obtained when insulin-related variables were added to models that additionally included glycemic control, cardiovascular risk factors, and depression.<br />Conclusions: Our results show that measures of peripheral insulin resistance are unrelated to cognitive performance among individuals with adequately controlled type 2 diabetes.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Biomarkers blood
Cognitive Dysfunction epidemiology
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Female
Glycated Hemoglobin analysis
Humans
Hyperinsulinism blood
Hyperinsulinism complications
Linear Models
Male
Middle Aged
Netherlands epidemiology
Neuropsychological Tests
Prospective Studies
Registries
Risk Factors
Aging
Cognitive Dysfunction complications
Diabetes Mellitus, Type 2 metabolism
Hyperinsulinism metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 28319003
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2017.01.020