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Expanding the tetrahydroquinoline pharmacophore.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Apr 15; Vol. 27 (8), pp. 1714-1720. Date of Electronic Publication: 2017 Mar 06. - Publication Year :
- 2017
-
Abstract
- Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Antitubercular Agents chemical synthesis
Antitubercular Agents chemistry
Antitubercular Agents pharmacology
Cattle
Cell Line, Tumor
Cycloaddition Reaction
Drug Discovery
Humans
Mycobacterium bovis drug effects
Neurogenesis drug effects
Quinolines chemical synthesis
Small Molecule Libraries chemical synthesis
Tuberculosis, Bovine drug therapy
Tuberculosis, Bovine microbiology
Quinolines chemistry
Quinolines pharmacology
Small Molecule Libraries chemistry
Small Molecule Libraries pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 27
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 28318941
- Full Text :
- https://doi.org/10.1016/j.bmcl.2017.02.077