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Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages.

Authors :
Dandela R
Mashiach R
Adepu R
Gregor R
Athamna M
Zecharia E
Ernst O
Zor T
Meijler MM
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Mar 30; Vol. 53 (27), pp. 3842-3845.
Publication Year :
2017

Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.

Details

Language :
English
ISSN :
1364-548X
Volume :
53
Issue :
27
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
28317057
Full Text :
https://doi.org/10.1039/c6cc09849e