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Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Mar 30; Vol. 53 (27), pp. 3842-3845. - Publication Year :
- 2017
-
Abstract
- Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.
- Subjects :
- Animals
Ceramides chemical synthesis
Ceramides chemistry
Dose-Response Relationship, Drug
Lipopolysaccharides pharmacology
Macrophages immunology
Macrophages metabolism
Mice
Molecular Probes chemical synthesis
Molecular Probes chemistry
Molecular Structure
Photochemical Processes
RAW 264.7 Cells
Structure-Activity Relationship
Ceramides pharmacology
Immunomodulation drug effects
Macrophages drug effects
Molecular Probes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 53
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28317057
- Full Text :
- https://doi.org/10.1039/c6cc09849e